An epigenetic therapy for diffuse intrinsic pontine gliomas
- PMID: 25473916
- DOI: 10.1038/nm.3769
An epigenetic therapy for diffuse intrinsic pontine gliomas
Abstract
Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.
Comment on
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Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.Nat Med. 2014 Dec;20(12):1394-6. doi: 10.1038/nm.3716. Epub 2014 Nov 17. Nat Med. 2014. PMID: 25401693 Free PMC article.
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