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Review
. 2015 Feb;29(1):135-51.
doi: 10.1016/j.hoc.2014.09.004.

Nonoperative management of rectal cancer: identifying the ideal patients

Angelita Habr-Gama  1 , Guilherme Pagin São Julião  2 , Rodrigo O Perez  3
Affiliations
Review

Nonoperative management of rectal cancer: identifying the ideal patients

Angelita Habr-Gama et al. Hematol Oncol Clin North Am. 2015 Feb.

Abstract

Neoadjuvant chemoradiation (CRT) is considered one of the preferred treatment strategies for patients with locally advanced rectal cancer. This strategy may lead to significant tumor regression, ultimately leading to a complete pathologic response in up to 42% of patients. Assessment of tumor response following CRT and before radical surgery may identify patients with a complete clinical response who could possibly be managed nonoperatively with strict follow-up (watch-and-wait strategy). The present article deals with critical issues regarding appropriate selection of patients for this approach.

Keywords: Complete clinical response; Neoadjuvant chemoradiation therapy; Rectal cancer; Watch and wait.

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