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Randomized Controlled Trial
. 2015 Jan 1;20(1):e111-6.
doi: 10.4317/medoral.19999.

Evaluation of osteoblastic activity in extraction sockets treated with platelet-rich fibrin

Ozgur Baslarli  1 , Celal Tumer, Omer Ugur, Betul Vatankulu
Affiliations
Randomized Controlled Trial

Evaluation of osteoblastic activity in extraction sockets treated with platelet-rich fibrin

Ozgur Baslarli et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objective: The aim of this study was to determine whether the use of platelet rich fibrin (PRF) improved the healing of extraction sockets.

Study design: A total of 20 patients with bilateral soft tissue impacted mandibular third molars were included in this study. The left and right third molars were extracted during the same session. Subsequently, the PRF membrane was randomly administered to one of the extraction sockets, whereas the contralateral sockets were left without treatment. On postoperative 30. and 90. days, panoramic images and bone scintigrams were taken to evaluate the bone healing between PRF-treated and non-PRF-treated sockets. Also, periodontal evaluation was performed in the same control sessions. Dependent group t test for paired samples was used for statistical analysis.

Results: The average increase in technetium-99m methylene diphosphonate uptake as an indication of enhanced bone healing did not differ significantly between PRF-treated and non-PRF-treated sockets 30 and 90 days postoperatively. Radio-opacity that can show the bone healing on panoramic images were measured by Image J programme and they did not differ significantly. Also periodontal values did not differ significantly.

Conclusions: PRF might not lead to enhanced bone healing in impacted mandibular third molar extraction sockets 30 and 90 days after surgery. It is thought that PRF has the potential characteristics of an autologous fibrin matrix and can accelerate the healing. To better understand the effects of PRF on healing, further research is warranted with larger sample sizes.

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Conflict of interest statement

Conflict of interest statement: The authors have declared that no conflict of interest exist.

Figures

Figure 1
Figure 1
Regions of interest drawn on the scintigram to indicate extraction socket regions and the frontal bone of calvarium.
Figure 2
Figure 2
The averages of Tc-99 methylene diphosphonate uptake in PRF treated and non-PRF treated sockets in the first and third months.
Figure 3
Figure 3
The average mean gray value scores of the bone obtained from panoramic radiographs in the first and third months.
See this image and copyright information in PMC

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References

    1. Chang IC, Tsai CH, Chang YC. Platelet-rich fibrin modulates the expression of extracellular signal-regulated protein kinase and osteoprotegerin in human osteoblasts. Journal of biomedical materials research Part A. 2010;95:327–32. - PubMed
    1. Giannobile WV. Periodontal tissue engineering by growth factors. Bone. 1996;19:23S–37S. - PubMed
    1. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:37–44. - PubMed
    1. Li Q, Reed DA, Min L, Gopinathan G. Lyophilized platelet-rich fibrin (PRF) promotes craniofacial bone regeneration through Runx2. Int J Mol Sci. 2014;15:8509–25. - PMC - PubMed
    1. Del Fabbro M, Bortolin M, Taschieri S. Is autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review. Int J Oral Maxillofac Surg. 2011;40:891–900. - PubMed

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