Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun;79(6):1030-3.
doi: 10.1111/bcp.12568.

Blood pressure-lowering effects of propofol or sevoflurane anaesthesia are not due to enhanced nitric oxide formation or bioavailability

Dimitrios Tsikas  1 , Jens Jordan  2 , Stefan Engeli  2
Affiliations

Blood pressure-lowering effects of propofol or sevoflurane anaesthesia are not due to enhanced nitric oxide formation or bioavailability

Dimitrios Tsikas et al. Br J Clin Pharmacol. 2015 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Nitrite (NO2) and nitrate (NO3) plasma concentrations during the first hour (0, 10, 30 and 60 min) of general anaesthesia with either propofol (P, n = 18) or thiopental/sevoflurane (S, n = 14). Data are shown as mean values ± SEM. Two-tailed Mann–Whitney U-test was used to test statistical significance. None of the comparisons yielded statistical significance between the groups (P > 0.05)
See this image and copyright information in PMC

References

    1. Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7:249–271. - PubMed
    1. Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of γ-aminobutyric acid (GABA) current at the GABAA receptor but not with lipid solubility. J Pharmacol Exp Ther. 2001;297:338–351. - PubMed
    1. Holaday DA, Smith FR. Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers. Anesthesiology. 1981;54:100–106. - PubMed
    1. Hilton P, Dev VJ, Major E. Intravenous anaesthesia with propofol and alfentanil. The influence of age and weight. Anaesthesia. 1986;41:640–643. - PubMed
    1. Ebert TJ, Muzi M, Berens R, Goff D, Kampine JP. Sympathetic responses to induction of anesthesia in humans with propofol or etomidate. Anesthesiology. 1992;76:725–733. - PubMed

MeSH terms

LinkOut - more resources