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. 2015 Jan 9;33(3):417-21.
doi: 10.1016/j.vaccine.2014.11.036. Epub 2014 Dec 2.

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

David J Vance  1 , Yinghui Rong  1 , Robert N Brey 3rd  2 , Nicholas J Mantis  3
Affiliations

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

David J Vance et al. Vaccine. .

Abstract

In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.

Keywords: Antigen; Biodefense; Toxin; Vaccine.

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Figures

Figure 1
Figure 1. Endpoint and toxin-neutralizing serum antibody titers elicited in mice following RiVax, DNI, and dual immunized mice
Mice were immunized with RiVax, DNI, or the combination of RiVax and DNI adsorbed to aluminum salts on days 0 and 20, as noted in the text. Sera were collected on days 20 and 200 and examined for (A) ricin- and PA-specific IgG antibodies and (B) ricin and LT toxin-neutralizing activities. Symbols and error bars represent means and standard deviations.
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