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Review
. 2015 Feb;25(1):141-53.
doi: 10.1016/j.nic.2014.09.010.

Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiology

Mohamed G ElBanan  1 , Ahmed M Amer  1 , Pascal O Zinn  2 , Rivka R Colen  3
Affiliations
Review

Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiology

Mohamed G ElBanan et al. Neuroimaging Clin N Am. 2015 Feb.

Abstract

Glioblastoma (GBM) is the most common and most aggressive primary malignant tumor of the central nervous system. Recently, researchers concluded that the "one-size-fits-all" approach for treatment of GBM is no longer valid and research should be directed toward more personalized and patient-tailored treatment protocols. Identification of the molecular and genomic pathways underlying GBM is essential for achieving this personalized and targeted therapeutic approach. Imaging genomics represents a new era as a noninvasive surrogate for genomic and molecular profile identification. This article discusses the basics of imaging genomics of GBM, its role in treatment decision-making, and its future potential in noninvasive genomic identification.

Keywords: 1p/19q; EGFR; Genetic biomarkers; Glioblastoma; IDH1; Imaging genomics; MGMT; Radiogenomics.

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