Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb;400(1-2):287-95.
doi: 10.1007/s11010-014-2285-y. Epub 2014 Dec 5.

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

Zhenyu Zhu  1 , Xukui Zhang, Hongliang Guo, Ling Fu, Ganlin Pan, Yinggang Sun
Affiliations

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

Zhenyu Zhu et al. Mol Cell Biochem. 2015 Feb.

Abstract

CXCL13, an inflammatory factor in the microenvironment, plays a vital role in the progression of inflammatory diseases and tumors. CXCL13 and its receptor CXCR5 have been reported to be associated with poor prognosis of advanced colon cancer. However, the molecular mechanisms of CXCL13-CXCR5 axis in colon cancer remain elusive. The aim of this study was to investigate the role of CXCR5-CXCL13 axis in the growth and invasion of colon cancer cells. Our results showed that CXCL13 promoted the growth, migration, and matrigel invasion of colon cancer cells. Furthermore, CXCL13 increased the expression and secretion of MMP-13, and stimulated the activation of PI3K/AKT pathway. After knockdown of CXCR5 by siRNA, the biological functions of colon cancer cells regulated by CXCL13 were significantly inhibited. In addition, inhibition of PI3K/AKT pathway by specific inhibitor LY294002 suppressed the CXCL13-mediated growth, migration, and invasion of colon cancer cells. Together, our findings suggest that CXCL13-CXCR5 axis promotes the growth, migration, and invasion of colon cancer cells, probably via PI3K/AKT pathway. Thus, CXCL13 may be a useful biomarker for the detection and treatment of colon cancer.

PubMed Disclaimer

References

    1. Chest. 2012 Apr;141(4):886-894 - PubMed
    1. Int J Cancer. 2010 May 15;126(10):2319-29 - PubMed
    1. Cell Signal. 2013 Aug;25(8):1711-9 - PubMed
    1. Br J Cancer. 2008 Sep 16;99(6):930-8 - PubMed
    1. Annu Rev Med. 2009;60:207-19 - PubMed

MeSH terms

LinkOut - more resources