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Editorial
. 2014 Dec 4;5(12):e1560.
doi: 10.1038/cddis.2014.516.

Old case, new leads: miRNA links Kaposi's sarcoma-associated herpesvirus with sepsis

W-T Lu  1 , M Bushell  1
Affiliations
Editorial

Old case, new leads: miRNA links Kaposi's sarcoma-associated herpesvirus with sepsis

W-T Lu et al. Cell Death Dis. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
KSHV binds the EphrinA (EphA) receptor. Viral binding leads to viral internalization via endocytosis, resulting in the viral genome being released into the nucleus. KSHV produces 25 viral miRNAs. Tudor et al. suggest that miR-K12-10b/12 may bind to TLR8 and activate cytokine production, in particular IL-6 and IL-10. It is unknown whether these two viral miRNAs post-transcriptionally regulate any host mRNA. Nevertheless, KSHV also transcribes miR-K12-11, which shares the same sequence as miR-155. This may induce the upregulation of TNFα proteins and further activation of the proinflammatory response, triggering sepsis
See this image and copyright information in PMC

Comment on

  • Cellular and Kaposi's sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma.
    Tudor S, Giza DE, Lin HY, Fabris L, Yoshiaki K, D'Abundo L, Toale KM, Shimizu M, Ferracin M, Challagundla KB, Cortez MA, Fuentes-Mattei E, Tulbure D, Gonzalez C, Henderson J, Row M, Rice TW, Ivan C, Negrini M, Fabbri M, Morris JS, Yeung SC, Vasilescu C, Calin GA. Tudor S, et al. Cell Death Dis. 2014 Dec 4;5(12):e1559. doi: 10.1038/cddis.2014.515. Cell Death Dis. 2014. PMID: 25476907 Free PMC article.

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