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. 2014:2014:252486.
doi: 10.1155/2014/252486. Epub 2014 Nov 12.

Major Cognitive Changes and Micrographia following Globus Pallidus Infarct

Sarah Nelson  1 , Hassanain Toma  2 , Haley LaMonica  3 , Tinatin Chabrashvili  3
Affiliations

Major Cognitive Changes and Micrographia following Globus Pallidus Infarct

Sarah Nelson et al. Case Rep Neurol Med. 2014.

Abstract

Importance. Globus pallidus (GP) lesions are well known to cause motor deficits but are less commonly-and perhaps not conclusively-associated with cognitive problems. Observations. We present a 45-year-old male with no significant neurological or psychological problems who after suffering a GP infarct was subsequently found to have substantial cognitive problems and micrographia. Formal neuropsychological testing was not possible due to lack of patient follow-up. Conclusions and Relevance. Despite the conflicting literature on the association of GP lesions and cognitive deficits, our patient demonstrated significant neuropsychological changes following his stroke. In addition, evidence of micrographia likely adds to the literature on the localization of this finding. Our case thus suggests that neuropsychological testing may be beneficial after GP strokes.

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Figures

Figure 1
Figure 1
Axial MRI of the brain. Diffusion weighted imaging sequence showing acute left globus pallidus infarct.
Figure 2
Figure 2
Handwriting samples. Micrographia was primarily demonstrated in the patient's right hand (designated “R”) as compared to his left hand (designated “L”).
See this image and copyright information in PMC

References

    1. Bhatia K. P., Marsden C. D. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain. 1994;117(4):859–876. doi: 10.1093/brain/117.4.859. - DOI - PubMed
    1. Münchau A., Mathen D., Cox T., Quinn N. P., Marsden C. D., Bhatia K. P. Unilateral lesions of the globus pallidus: report of four patients presenting with focal or segmental dystonia. Journal of Neurology, Neurosurgery & Psychiatry. 2000;69(4):494–498. doi: 10.1136/jnnp.69.4.494. - DOI - PMC - PubMed
    1. Ghika J., Ghika-Schmid F., Fankhauser H., Assal G., Vingerhoets F., Albanese A., Bogousslavsky J., Favre J. Bilateral contemporaneous posteroventral pallidotomy for the treatment of Parkinson's disease: Neuropsychological and neurological side effects: report of four cases and review of the literature. Journal of Neurosurgery. 1999;91(2):313–321. doi: 10.3171/jns.1999.91.2.0313. - DOI - PubMed
    1. Junque C., Alegret M., Nobbe F. A., et al. Cognitive and behavioral changes after unilateral posteroventral pallidotomy : relationship with lesional data from MRI. Movement Disorders. 1999;14(5):780–789. doi: 10.1002/1531-8257(199909)14:5<780::AID-MDS1010>3.0.CO;2-G. - DOI - PubMed
    1. Lombardi W. J., Gross R. E., Trepanier L. L., Lang A. E., Lozano A. M., Saint-Cyr J. A. Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease. Support for the existence of cognitive circuits in the human pallidum. Brain. 2000;123(4):746–758. doi: 10.1093/brain/123.4.746. - DOI - PubMed

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