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Comment
. 2014 Dec 4;15(6):669-70.
doi: 10.1016/j.stem.2014.11.011.

Stem cell RNA epigenetics: m(6)arking your territory

Aimee L Jalkanen  1 , Jeffrey Wilusz  2
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Comment

Stem cell RNA epigenetics: m(6)arking your territory

Aimee L Jalkanen et al. Cell Stem Cell. .
Free article

Abstract

Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit from pluripotency toward differentiation.

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  • m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
    Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY. Batista PJ, et al. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16. Cell Stem Cell. 2014. PMID: 25456834 Free PMC article.

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