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Comment
. 2014 Dec 4;15(6):673-5.
doi: 10.1016/j.stem.2014.11.014.

Pushing the limits: defeating leukemia stem cells by depleting telomerase

Ya-Huei Kuo  1 , Ravi Bhatia  2
Affiliations
Comment

Pushing the limits: defeating leukemia stem cells by depleting telomerase

Ya-Huei Kuo et al. Cell Stem Cell. .

Abstract

Leukemia stem cells (LSCs), featuring unlimited self-renewal capacity and chemoresistance, are critical cellular targets for new treatments to improve outcomes for acute myeloid leukemia (AML). In this issue of Cell Stem Cell, Bruedigam et al. (2014) demonstrate that inhibition of telomerase is damaging to LSCs and may represent a promising therapeutic approach in AML.

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Figures

Figure 1
Figure 1. Telomerase maintains leukemia stem cell (LSC) long-term self-renewal
Telomerase inhibition either genetically (Terc-deletion or shTERT) or pharmacologically (imetelstat) limits LSC self-renewal capacity through cell cycle arrest, p53 activation, DNA damage and apoptosis. Inhibition of telomerase represents a promising approach to combat long-lived and chemoresistant LSCs.
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Comment on

References

    1. Bruedigam C, Bagger FO, Heidel FH, Kuhn CP, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW. Cell Stem Cell. 2014;15 this issue. - PMC - PubMed
    1. Gessner A, Thomas M, Castro PG, Büchler L, Scholz A, Brümmendorf TH, Soria NM, Vormoor J, Greil J, Heidenreich O. Leukemia. 2010;24:1751–59. - PubMed
    1. Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, et al. Nat Commun. 2014;5:4599. - PubMed
    1. Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM. Oncogene. 2005;24:5262–68. - PubMed
    1. Pucci F, Gardano L, Harrington L. Cell Stem Cell. 2013;12:479–486. - PMC - PubMed

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