Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Dec 4;15(6):677-8.
doi: 10.1016/j.stem.2014.11.015.

Sleeping beauty wakes up the clonal succession model for homeostatic hematopoiesis

Rong Lu  1
Affiliations
Free article
Comment

Sleeping beauty wakes up the clonal succession model for homeostatic hematopoiesis

Rong Lu. Cell Stem Cell. .
Free article

Abstract

Recently in Nature, Sun et al. (2014) used a sleeping beauty transposon system to demonstrate that natural hematopoiesis is sustained by the successive recruitment of thousands of clones that are mostly lineage restricted. These findings call into question whether homeostatic hematopoiesis is sustained by hematopoietic stem cells traditionally identified by transplantation.

PubMed Disclaimer

Comment on

  • Clonal dynamics of native haematopoiesis.
    Sun J, Ramos A, Chapman B, Johnnidis JB, Le L, Ho YJ, Klein A, Hofmann O, Camargo FD. Sun J, et al. Nature. 2014 Oct 16;514(7522):322-7. doi: 10.1038/nature13824. Epub 2014 Oct 5. Nature. 2014. PMID: 25296256 Free PMC article.

LinkOut - more resources