Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Dec 6:14:176.
doi: 10.1186/1471-2261-14-176.

Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

Celestino Sardu, Giovanni Carreras, Spyridon Katsanos, Vasileios Kamperidis, Maria Caterina Pace, Maria Beatrice Passavanti, Ilaria Fava, Pasquale Paolisso, Gorizio Pieretti, Giovanni Francesco Nicoletti, Gaetano Santulli, Giuseppe Paolisso, Raffaele Marfella  1
Affiliations
Multicenter Study

Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

Celestino Sardu et al. BMC Cardiovasc Disord. .

Abstract

Background: The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease.

Methods: In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up.

Results: Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p < 0.001). In cox regression analysis, only MS was independently associated with study endpoint (HR = 9.655 , 95% CI 3.000-31.0.68 , p < 0.001).

Conclusions: MS is associated with a higher recurrence rate of outflow tract PVCs after CA in patients without structural heart disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Recurrence-free survival in patients with PVCs. Kaplan Meier curve showing survival free of study endpoint between patients with or without metabolic syndrome (Log-rank test, p < 0.001). MS = metabolic syndrome; PVCs = outflow tract premature ventricular contractions; Pts = patients.
See this image and copyright information in PMC

References

    1. Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Final reportCirculation 2002, 106:3143–3421. - PubMed
    1. Ford ES. The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the national health and nutrition examination survey II mortality study. Atherosclerosis. 2004;173:309–314. doi: 10.1016/j.atherosclerosis.2003.12.022. - DOI - PubMed
    1. Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, Williams GR. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004;110:1245–1250. doi: 10.1161/01.CIR.0000140677.20606.0E. - DOI - PubMed
    1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC, Jr, International Diabetes Federation Task Force on Epidemiology and Prevention Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120:1640–1645. doi: 10.1161/CIRCULATIONAHA.109.192644. - DOI - PubMed
    1. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care. 2005;28:1769–1778. doi: 10.2337/diacare.28.7.1769. - DOI - PubMed
Pre-publication history
    1. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2261/14/176/prepub

Publication types