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. 1989 Jun;9(6):2738-42.
doi: 10.1128/mcb.9.6.2738-2742.1989.

High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1

A S Kimball  1 , G Milman, T D Tullius
Affiliations

High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1

A S Kimball et al. Mol Cell Biol. 1989 Jun.

Abstract

The DNA-binding domain of Epstein-Barr virus nuclear antigen 1 was found by hydroxyl radical footprinting to protect backbone positions on one side of its DNA-binding site. The guanines contacted in the major groove by the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 were identified by methylation protection. No difference was found in the interaction of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 with tandemly repeated and overlapping binding sites.

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