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Review
. 2015 Jan 1;20(1):e34-44.
doi: 10.4317/medoral.19157.

Odontogenic tumors: a collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature

Ahmet-Ercan Sekerci  1 , Sinan Nazlim, Meryem Etoz, Kemal Deniz, Yasin Yasa
Affiliations
Review

Odontogenic tumors: a collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature

Ahmet-Ercan Sekerci et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objectives: The objective of this study was to analyze the frequency and distribution of odontogenic tumors (OTs) in the Cappadocia region of Turkey, and to compare the findings with those reported in the literature.

Study design: The records of the Oral and Maxillofacial Surgery and Pathology Departments at Erciyes University, with histologic diagnosis of odontogenic tumors (based on the World Health Organization classification, 2005), over a 12-year period, were analyzed. The relative frequency of different types of tumors was also analyzed and compared with the literature.

Results: OTs in the present study constituted 2.74% of all the 7,942 registered biopsies. A total of 218 cases of OTs were collected and reviewed. Of these, (94.04%) were benign and (5.96%) were malignant. The mandible was the most commonly affected anatomic location, with 170 cases (77.9%). Ameloblastoma with a predilection for the posterior mandible was the most frequent odontogenic tumor (30.28%), followed by keratocystic odontogenic tumor (19.5%), odontoma (13.4%), and odontogenic myxoma (8.5%).

Conclusions: OTs are rare neoplasms and appear to show geographic variations in the world. In Cappadocia, Turkey, they are more common in the mandible, with ameloblastoma followed by keratocystic odontogenic tumors with the incidences observed in the present study being similar to those of previous studies from Asia and Africa, and in contrast to those reported from American countries.

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Conflict of interest statement

Conflict of interest statement: The authors have declared that no conflict of interest exist.

Figures

Figure 1
Figure 1
Examples of odontogenic tumors diagnosed with histopathological examination. a) Adenomatoid odontogenic tumor, H&Ex100; b) Calcifying epithelial odontogenic tumor, H&Ex100; c) Odontogenic fibroma, H&Ex100; d) Ameloblastoma, H&Ex100; e) Cementoblastoma, H&Ex100; f) Komplex odontoma, H&Ex100; g) Kompound odontoma, H&Ex40; h) Ameloblastic carcinoma, H&Ex100; i) Keratocystic odontogenic tumor, H&Ex100.
Figure 2
Figure 2
Examples of cropped panoramic radiographs of patients with odontogenic tumors: a) Odontogenic myxoma, b) Ameloblastik fibro-odontom; c) Odontoma.
See this image and copyright information in PMC

References

    1. Philipsen HP, Reichart PA. Revision of the 1992-edition of the WHO histological typing of odontogenic tumours. A suggestion. J Oral Pathol Med. 2002;31:253–8. - PubMed
    1. Mosqueda-Taylor A. New findings and controversies in odontogenic tumors. Med Oral Patol Oral Cir Bucal. 2008;13:E555–8. - PubMed
    1. Regezi JA, Kerr DA, Courtney RM. Odontogenic tumors: analysis of 706 cases. J Oral Surg. 1978;36:771–8. - PubMed
    1. Lawal AO, Adisa AO, Olusanya AA. Odontogenic tumors: a review of 266 cases. J Clin Exp Dent. 2013;5:e13–7. - PMC - PubMed
    1. Gupta B, Ponniah I. The pattern of odonto-genic tumors in a government teaching hos-pital in the southern Indian state of Tamil Nadu. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:32–9. - PubMed

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