Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar;16(1-2):1-7.
doi: 10.3109/21678421.2014.964258. Epub 2014 Dec 8.

The El Escorial criteria: strengths and weaknesses

Federica Agosta  1 , Ammar Al-Chalabi, Massimo Filippi, Orla Hardiman, Ryuji Kaji, Vincent Meininger, Imaharu Nakano, Pamela Shaw, Jeremy Shefner, Leonard H van den Berg, Albert Ludolph; WFN Research Group on ALS/MND
Affiliations

The El Escorial criteria: strengths and weaknesses

Federica Agosta et al. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Mar.

Abstract

The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes.

Keywords: ALS; El Escorial.

PubMed Disclaimer

MeSH terms

LinkOut - more resources