Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014;13(20):3159-60.
doi: 10.4161/15384101.2014.969996.

Treg identity protection by an epigenetic switch

Xudong Li  1 , Ye Zheng
Affiliations
Editorial

Treg identity protection by an epigenetic switch

Xudong Li et al. Cell Cycle. 2014.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
CNS2 protects Treg cell identity. Methylated CNS2 in Treg precursors prevents it from interfering with normal Treg differentiation. Demethylated CNS2 interacts with Foxp3 promoter in a T cell receptor (TCR) and NFAT dependent manner to promote and stabilize Foxp3 expression when mature Tregs are activated and exposed to diverse signals that shape Treg function.
See this image and copyright information in PMC

Comment on

References

    1. Sakaguchi S, et al. . Cell 2008; 133:775-87; PMID:18510923; http://dx.doi.org/10.1016/j.cell.2008.05.009 - DOI - PubMed
    1. Josefowicz SZ, et al. . Ann Rev Immunol 2012; 30:531-64; PMID:22224781; http://dx.doi.org/10.1146/annurev.immunol.25.022106.141623 - DOI - PMC - PubMed
    1. Williams LM, et al. . Nat Immunol 2007; 8:277-84; PMID:17220892; http://dx.doi.org/10.1038/ni1437 - DOI - PubMed
    1. Zheng Y, et al. . Nature 2010; 463:808-12; PMID:20072126; http://dx.doi.org/10.1038/nature08750 - DOI - PMC - PubMed
    1. Floess S, et al. . PLoS Biol 2007; 5:e38; PMID:17298177; http://dx.doi.org/10.1371/journal.pbio.0050038 - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources