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Editorial
. 2014;13(21):3315-6.
doi: 10.4161/15384101.2014.972919.

mTOR: a gate to NK cell maturation and activation

Antoine Marçais  1 , Thierry Walzer
Affiliations
Editorial

mTOR: a gate to NK cell maturation and activation

Antoine Marçais et al. Cell Cycle. 2014.
No abstract available

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Figures

Figure 1.
Figure 1.
(A) In homeostatic conditions, mature NK cells are exposed to low IL-15 concentration triggering STAT5 phosphorylation and translocation to the nucleus where pro-survival genes are transcribed. (B) Immature NK cells in the BM or mature NK cells following activation are exposed to high IL-15 concentration leading to mTOR activation of metabolism. This induces proliferation and the development of effector functions.
See this image and copyright information in PMC

Comment on

References

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