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Editorial

. 2014;13(16):2483-4.

doi: 10.4161/15384101.2014.947228.

ELMO3: a direct driver of cancer metastasis?

Lasse Sommer Kristensen¹, Signe Søes, Lise Lotte Hansen

Affiliations

PMID: 25486185
PMCID: PMC4614988
DOI: 10.4161/15384101.2014.947228

Editorial

ELMO3: a direct driver of cancer metastasis?

Lasse Sommer Kristensen et al. Cell Cycle. 2014.

. 2014;13(16):2483-4.

doi: 10.4161/15384101.2014.947228.

Authors

Lasse Sommer Kristensen¹, Signe Søes, Lise Lotte Hansen

Affiliation

¹ a Department of Hematology; Rigshospitalet , Copenhagen , Denmark.

PMID: 25486185
PMCID: PMC4614988
DOI: 10.4161/15384101.2014.947228

No abstract available

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Figures

Figure 1. — Figure 1.
Simplified model of somatic evolution during cancer progression. Cancer cells are characterized by molecular alterations (indicated as color changes of the cells) leading to increased proliferation, such as inactivation of growth-suppressing- and pro-apoptotic genes, as well as activation of growth promoting oncogenes. The pace of the evolution is fuelled by defects in DNA repair genes or modifiers of the epigenome. These alterations may be regarded as indirect drivers of metastasis, and only additional alterations directly linked to the multi-step process of metastasis may distinguish cancer cells with metastatic capabilities from those without. As these alterations often precede the presence of detectable metastases, their characterization is not straightforward.

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