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Editorial
. 2014;13(17):2647-8.
doi: 10.4161/15384101.2014.954212.

Targeting cardiac fibroblasts: the pressure is on

Thomas Moore-Morris  1 , Michel Pucéat, Sylvia M Evans
Affiliations
Editorial

Targeting cardiac fibroblasts: the pressure is on

Thomas Moore-Morris et al. Cell Cycle. 2014.
No abstract available

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Figures

Figure 1.
Figure 1.
Cardiac fibroblast markers and lineages following pressure-overload. At baseline and following pressure overload, all fibroblasts are marked by Collagen1a1-GFP and PDGFRα. FSP1 labels most haematopoietic cells and a subset of fibroblasts (50%) in perivascular areas. αSMA labels a small subset of fibroblasts (15%) in interstitial lesions. Spatially complementary endocardial- and epicardial-derived lineages behave similarly following pressure overload.
See this image and copyright information in PMC

Comment on

  • Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.
    Moore-Morris T, Guimarães-Camboa N, Banerjee I, Zambon AC, Kisseleva T, Velayoudon A, Stallcup WB, Gu Y, Dalton ND, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner DA, Peterson KL, Chen J, Evans SM. Moore-Morris T, et al. J Clin Invest. 2014 Jul;124(7):2921-34. doi: 10.1172/JCI74783. Epub 2014 Jun 17. J Clin Invest. 2014. PMID: 24937432 Free PMC article.

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