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Editorial
. 2014;13(19):2990-1.
doi: 10.4161/15384101.2014.962865.

Flippases and scramblases in the plasma membrane

Katsumori Segawa  1 , Jun Suzuki, Shigekazu Nagata
Affiliations
Editorial

Flippases and scramblases in the plasma membrane

Katsumori Segawa et al. Cell Cycle. 2014.
No abstract available

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Figures

Figure 1.
Figure 1.
Phospholipids at plasma membranes. In normal cells, phospholipids are asymmetrically distributed between inner and outer leaflets by the function of flippase (ATP11C). During apoptosis, caspases cleave ATP11C to inactivate it, while activating Xkr8 to scramble phospholipids, thus exposing phosphatidylserine to the cell surface. In platelet activation, a high intracellular Ca2+ appears to inactivate ATP11C, while it activates TMEM16-supported phospholipid scrambling.
See this image and copyright information in PMC

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References

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