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. 1989 Aug;77(2):189-94.
doi: 10.1042/cs0770189.

Serum digoxin-like substances in pregnancy-induced hypertension

L Poston  1 , J F Morris, C D Wolfe, P J Hilton
Affiliations

Serum digoxin-like substances in pregnancy-induced hypertension

L Poston et al. Clin Sci (Lond). 1989 Aug.

Abstract

1. Endogenous digoxin-like immunoreactivity (EDLI) was measured in the serum of 85 normotensive pregnant (NTP) women and 77 women with pregnancy-induced hypertension (PIH) by a radioimmunoassay (New England Nuclear). All women were in the third trimester. 2. EDLI, which was undetectable in serum from non-pregnant women, was present in NTP and PIH and was significantly higher in PIH. EDLI correlated with gestational age in NTP, but not in PIH. 3. Ouabain-sensitive Na+ transport was estimated in normal peripheral blood leucocytes after incubation with sera from 50 NTP and 42 PIH women. Significant inhibition of active Na+ transport occurred only with the serum of hypertensive patients without proteinuria. 4. EDLI did not correlate with the effect of the sera on active Na+ transport. The radioimmunoassay therefore provides a poor index of Na+ transport inhibitory activity in PIH.

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