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. 1989 Jun;8(6):1801-8.
doi: 10.1002/j.1460-2075.1989.tb03574.x.

A point mutation in the CYC1 UAS1 creates a new combination of regulatory elements that activate transcription synergistically

R Sousa  1 , B Arcangioli
Affiliations

A point mutation in the CYC1 UAS1 creates a new combination of regulatory elements that activate transcription synergistically

R Sousa et al. EMBO J. 1989 Jun.

Abstract

Dissection of the upstream activation site 1 (UAS1) of the yeast CYC1 gene showed that the A and B regions respond individually to regulation by the HAP1 protein, and that a point mutation in the B region converts this region to a translation upstream factor (TUF)-regulated element. Combinatorial analyses revealed that the transacting factors involved with these wild-type and mutant UAS1 target sites combine to activate transcription in a synergistic manner. Furthermore, combinations of heterologous factors, made possible by the point mutation, create a new specificity of regulation that differs from regulation by any one factor individually.

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References

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