Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec 4;13(1):37.
doi: 10.1186/s12991-014-0037-8. eCollection 2014.

Depression and attempted suicide under pregabalin therapy

Affiliations

Depression and attempted suicide under pregabalin therapy

Andreas Kustermann et al. Ann Gen Psychiatry. .

Abstract

Originally developed for the treatment of epilepsy, pregabalin has become a compound with a wide spectrum of indications comprising anxiety disorders and chronic pain and is therefore largely prescribed. Thus, it is important for clinicians to be aware of rare, but serious adverse effects. The following report illustrates the case of a 20-year-old male with a severe depressive syndrome following pregabalin medication which even led to a suicide attempt.

Keywords: Anticonvulsants; Depression; Pregabalin; Suicide.

PubMed Disclaimer

References

    1. US Food and Drug Administration . ᅟ. ᅟ. Antiepileptic drugs and suicidality.
    1. Andersohn F, Schade R, Willich SN, Garbe E. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology. 2010;75:335–340. doi: 10.1212/WNL.0b013e3181ea157e. - DOI - PubMed
    1. Mutschler J, Grosshans M, Herwig U, Heekeren K, Kawohl W, Bruhl A. Pregabalin-induced suicidal ideations. Pharmacopsychiatry. 2011;44:119. doi: 10.1055/s-0031-1271689. - DOI - PubMed
    1. Gibbons RD, Hur K, Brown CH, Mann JJ. Relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder. Arch Gen Psychiatry. 2009;66:1354–1360. doi: 10.1001/archgenpsychiatry.2009.159. - DOI - PMC - PubMed
    1. Arana A, Wentworth CE, Ayuso-Mateos JL, Arellano FM. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med. 2010;363:542–551. doi: 10.1056/NEJMoa0909801. - DOI - PubMed