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Review
. 2013 Dec 17;5(6):394-405.
doi: 10.14336/AD.2014.0500394. eCollection 2014 Dec.

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

Catherine Baugé  1 , Nicolas Girard  1 , Eva Lhuissier  1 , Celine Bazille  2 , Karim Boumediene  1
Affiliations
Review

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

Catherine Baugé et al. Aging Dis. .

Abstract

Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.

Keywords: TGFbeta; aging; chondrocytes; osteoarthritis.

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Figures

Figure 1.
Figure 1.
Role of TGF-beta in healthy and OA cartilage. TGFβ signals through TβRII and ALK5 in young and healthy cartilage eliciting chondrogenic factors. In aged or AO cartilage, TβRII and ALK5 breakdown occurs while ALK1 expression is enhanced. Therefore, TGFβ signalling shifts from Smad2/3 to Smad 1/5/8 leading to COL10 and MMP13 expression.
See this image and copyright information in PMC

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