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Review
. 2014 Nov;2(11):109.
doi: 10.3978/j.issn.2305-5839.2014.10.04.

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere  1 , Pietro Fici  1 , Giulia Gallerani  1 , Francesco Fabbri  1 , Wainer Zoli  1 , Michel Rigaud  1
Affiliations
Review

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere et al. Ann Transl Med. 2014 Nov.

Abstract

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.

Keywords: Circulating tumor cells (CTCs); epithelial mesenchymal transition (EMT); stemness.

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