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Comment
. 2014 Dec 8;26(6):783-784.
doi: 10.1016/j.ccell.2014.11.012.

Treating transcriptional addiction in small cell lung cancer

Arnaud Augert  1 , David MacPherson  2
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Treating transcriptional addiction in small cell lung cancer

Arnaud Augert et al. Cancer Cell. .
Free article

Abstract

Small cell lung cancer (SCLC) is a devastating tumor type with great therapeutic need. In this issue of Cancer Cell, Christensen and colleagues identify THZ1, a CDK7 inhibitor, as a potential therapy for SCLC. Using cells and mouse models, the authors show exquisite sensitivity of SCLC to transcriptional inhibition.

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  • Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
    Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel JB, Cavanaugh JD, Gao P, Liu Y, Michaelsen SR, Poulsen HS, Aref AR, Barbie DA, Bradner JE, George RE, Gray NS, Young RA, Wong KK. Christensen CL, et al. Cancer Cell. 2014 Dec 8;26(6):909-922. doi: 10.1016/j.ccell.2014.10.019. Cancer Cell. 2014. PMID: 25490451 Free PMC article.

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