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Meta-Analysis
. 2014 Dec;35(12):1463-8.

Effects of stem cell therapy on dilated cardiomyopathy

Rong Jiao  1 , Yuan Liu, Wen-Jian Yang, Xiao-Yan Zhu, Jin Li, Qi-Zhu Tang
Affiliations
Meta-Analysis

Effects of stem cell therapy on dilated cardiomyopathy

Rong Jiao et al. Saudi Med J. 2014 Dec.

Abstract

Objectives: To perform a meta-analysis of clinical trials and investigate the effect of stem cell therapy on dilated cardiomyopathy.

Methods: A systematic literature search was carried out between May 2012 and July 2013 in PubMed, Medline, Cochrane Library, and Excerpta Medica Database (EMBASE). The study took place in the Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China. The weighted mean difference (WMD) was calculated for left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), mortality and heart transplantation, and the 6-minute walk test (6-MWT) distance using the RevMan 5.0 software.

Results: Seven trials with 599 participants evaluated the association between the stem cell therapy and control groups. Compared with the control group, stem cell therapy group improved the LVEF (WMD: 3.98%, 95% confidence interval [CI]: 0.55 - 7.41%, p=0.02) and the 6-MWT distance (WMD: 132.12 m, 95% CI: 88.15-176.09 m, p<0.00001), and reduced mortality and heart transplantation (odds ratio [OR]: 0.48, 95% CI: 0.29-0.80, p=0.005). However, the LVEDD showed no significant difference between the 2 groups (WMD: -1.53 mm, 95% CI: -1.15-0.10 mm, p=0.10).

Conclusion: This meta-analysis demonstrated that stem cell therapy improves cardiac function and reduces mortality in dilated cardiomyopathy patients, which suggested that stem cell therapy may represent a new therapy option for dilated cardiomyopathy.

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Figures

Figure 1
Figure 1
Flowchart of the study selection among 415 citations initially excluded at the title/abstract level.
Figure 2
Figure 2
Forrest Plot and WMD for A) LVEF, B) LVEDD, C) 6-minute walk test distance, D) mortality and heart transplantation. WMD - weight mean difference, LVEF - left ventricular ejection fraction, LVEDD - left ventricular end-diastolic diameter, OR - odds ratio, CI - confidence interval
Figure 3
Figure 3
Funnel plot of SE to evaluate publication bias for effect of stem cell therapy in mortality and heart transplantation. SE - Standard error
See this image and copyright information in PMC

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