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. 2015 Mar 21;44(11):4874-83.
doi: 10.1039/c4dt02977a.

Towards the elaboration of new gold-based optical theranostics

Pierre-Emmanuel Doulain  1 , Richard Decréau, Cindy Racoeur, Victor Goncalves, Laurence Dubrez, Ali Bettaieb, Pierre Le Gendre, Franck Denat, Catherine Paul, Christine Goze, Ewen Bodio
Affiliations

Towards the elaboration of new gold-based optical theranostics

Pierre-Emmanuel Doulain et al. Dalton Trans. .

Abstract

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

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