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Comparative Study
. 2014 Dec 7;20(45):17120-6.
doi: 10.3748/wjg.v20.i45.17120.

Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea

Sook Hee Chung  1 , Soo Jung Park  1 , Hye Sun Lee  1 , Sung Pil Hong  1 , Jae Hee Cheon  1 , Tae Il Kim  1 , Won Ho Kim  1
Affiliations
Comparative Study

Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea

Sook Hee Chung et al. World J Gastroenterol. .

Abstract

Aim: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

Methods: We obtained clinical data on Crohn's disease (CD) (n = 691) and ulcerative colitis (n = 1113) from a tertiary referral medical center between 2005 and 2012. Seventeen patients (2.5%) with CD and 27 patients (2.4%) with ulcerative colitis (UC) were identified as having a familial history of IBD, including the first and second degree relatives. For each control case, three times the number of age-, sex-, and diagnosis year-matched CD and UC patients, without a family history of IBD, were randomly selected in this case control study.

Results: There were no significant differences in age or main symptom at diagnosis, extraintestinal manifestation, location/extent, behavior of disease activity, number of hospitalizations, number of operations, operation type, number of relapses, or oral medical treatment between familial and sporadic CD and UC patients. Median (min-max) follow-up periods after diagnosis of familial CD and sporadic CD patients were 84 (24-312) and 36 (8-240) mo, respectively (P = 0.008). Familial CD patients more frequently used anti-tumor necrosis factor (TNF) antibodies compared to sporadic CD patients (17.6% vs 0%, P = 0.014).

Conclusion: In conclusion, a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients.

Keywords: Clinical characteristics; Crohn’s disease; Family history; Inflammatory bowel disease; Ulcerative colitis.

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Figures

Figure 1
Figure 1
Family relations and relatives of familial Crohn’s disease. CD: Crohn's disease; UC: Ulcerative colitis.
Figure 2
Figure 2
Family relations and relatives of familial ulcerative colitis. CD: Crohn's disease; UC: Ulcerative colitis.
See this image and copyright information in PMC

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