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Comment
. 2014;13(22):3467-8.
doi: 10.4161/15384101.2014.980695.

DDX17: structured RNA recognition drives diverse outputs

Ryan H Moy  1 , Sara Cherry
Affiliations
Comment

DDX17: structured RNA recognition drives diverse outputs

Ryan H Moy et al. Cell Cycle. 2014.
No abstract available

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Figures

Figure 1.
Figure 1.
DDX17 recognizes both primary sequence elements and secondary structures of RNAs. CLIP-seq analysis of DDX17-bound RNAs revealed that DDX17 recognizes mature cellular mRNAs enriched for CA- and CT-repeat elements. DDX17 is a member of the Microprocessor complex and facilitates pri-miRNA processing, but not through these repeat elements. Rather, DDX17 is localized to the stem region and cooperates with a previously described [GTA]CATC[CTA] element, and together may determine DDX17 binding to miRNAs. In the cytoplasm, DDX17 binds to viral RNAs by recognizing structured regions such as the intergenic stem loop on the RVFV S genomic RNA to inhibit viral RNA replication.
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References

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