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Multicenter Study
. 2014 Dec 10;9(12):e110393.
doi: 10.1371/journal.pone.0110393. eCollection 2014.

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa

Florian Gehre  1 , Mebrat Ejo  2 , Kristina Fissette  2 , Pim de Rijk  2 , Cécile Uwizeye  2 , Elie Nduwamahoro  2 , Odin Goovaerts  2 , Dissou Affolabi  3 , Martin Gninafon  3 , Fanny M Lingoupou  4 , Mamadou Dian Barry  5 , Oumou Sow  5 , Corinne Merle  6 , Piero Olliaro  7 , Fatoumata Ba  8 , Marie Sarr  9 , Alberto Piubello  10 , Juergen Noeske  11 , Martin Antonio  12 , Leen Rigouts  2 , Bouke C de Jong  13
Affiliations
Multicenter Study

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa

Florian Gehre et al. PLoS One. .

Abstract

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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