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. 2015 Feb;104(2):144-51.
doi: 10.5935/abc.20140190. Epub 2014 Dec 9.

Neural mechanisms and delayed gastric emptying of liquid induced through acute myocardial infarction in rats

[Article in English, Portuguese]
Wilson Ranu Ramirez Nunez  1 , Michiko Regina Ozaki  1 , Adriana Mendes Vinagre  1 , Edgard Ferro Collares  1 , Eros Antonio de Almeida  1
Affiliations

Neural mechanisms and delayed gastric emptying of liquid induced through acute myocardial infarction in rats

[Article in English, Portuguese]
Wilson Ranu Ramirez Nunez et al. Arq Bras Cardiol. 2015 Feb.

Abstract

Background: In pathological situations, such as acute myocardial infarction, disorders of motility of the proximal gut can trigger symptoms like nausea and vomiting. Acute myocardial infarction delays gastric emptying (GE) of liquid in rats.

Objective: Investigate the involvement of the vagus nerve, α 1-adrenoceptors, central nervous system GABAB receptors and also participation of paraventricular nucleus (PVN) of the hypothalamus in GE and gastric compliance (GC) in infarcted rats.

Methods: Wistar rats, N = 8-15 in each group, were divided as INF group and sham (SH) group and subdivided. The infarction was performed through ligation of the left anterior descending coronary artery. GC was estimated with pressure-volume curves. Vagotomy was performed by sectioning the dorsal and ventral branches. To verify the action of GABAB receptors, baclofen was injected via icv (intracerebroventricular). Intravenous prazosin was used to produce chemical sympathectomy. The lesion in the PVN of the hypothalamus was performed using a 1 mA/10 s electrical current and GE was determined by measuring the percentage of gastric retention (% GR) of a saline meal.

Results: No significant differences were observed regarding GC between groups; vagotomy significantly reduced % GR in INF group; icv treatment with baclofen significantly reduced %GR. GABAB receptors were not conclusively involved in delaying GE; intravenous treatment with prazosin significantly reduced GR% in INF group. PVN lesion abolished the effect of myocardial infarction on GE.

Conclusion: Gastric emptying of liquids induced through acute myocardial infarction in rats showed the involvement of the vagus nerve, alpha1- adrenergic receptors and PVN.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figura 1
Figura 1
Results of gastric retention (%) in groups of rats with myocardial infarction (INF) and vagotomy (Vg) * p < 0.05.
Figura 2
Figura 2
Results of gastric retention (%) in groups of rats with myocardial infarction and inserted metal probe, with baclofen (BAC) or saline (V) injected into the lateral ventricle of the brain * p <0.05.
Figura 3
Figura 3
Results of gastric retention (%) in groups of rats with myocardial infarction that received prazosin (PRA) or Saline (V) injection * p < 0.05.
Figura 4
Figura 4
Results of gastric retention (%) in groups of rats with myocardial infarction and lesions of the paraventricular nucleus * p < 0.05.
See this image and copyright information in PMC

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