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Comment
. 2014;13(24):3796-7.
doi: 10.4161/15384101.2014.986630.

Complex DSBs: A need for resection

Anthony J Davis  1 , David J Chen
Affiliations
Comment

Complex DSBs: A need for resection

Anthony J Davis et al. Cell Cycle. 2014.
No abstract available

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Figures

Figure 1.
Figure 1.
DNA end resection is required for repair of complex DSBs. Low LET irradiation generates simple DSBs, which are repaired by NHEJ in G1 and by NHEJ or HR in S/G2. High LET irradiation generates complex DSBs. Complex DSBs are resected in all cell cycle phases by Exo1/CtIP/Mre11 to generate stretches of ssDNA that are bound by RPA. It is still unknown which DSB repair pathway repairs complex DSBs in G1.
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Comment on

References

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