The potential of 12/15-lipoxygenase inhibitors in stroke therapy
- PMID: 25495979
- PMCID: PMC4280907
- DOI: 10.4155/fmc.14.129
The potential of 12/15-lipoxygenase inhibitors in stroke therapy
Keywords: edema; eicosanoid; hemorrhage; ischemia; lipoxygenase; oxidative stress; stroke; tissue plasminogen activator.
Conflict of interest statement
The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
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References
-
- Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J. Med. Chem. 2006;49(4):1356–1363. - PubMed
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