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Editorial
. 2015 Apr;24(4):258-9.
doi: 10.1111/exd.12618.

The role of melanin pigment in melanoma

Radomir M Slominski  1 , Michal A Zmijewski, Andrzej T Slominski
Affiliations
Editorial

The role of melanin pigment in melanoma

Radomir M Slominski et al. Exp Dermatol. 2015 Apr.
No abstract available

Keywords: melanin; melanocytes; melanoma; melanosomes; metastatic phenotype.

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Figures

Figure 1
Figure 1
Complex interactions between melanogenesis and cellular metabolism in melanoma cells. SM, stimulators of melanogenesis; ROS, reactive oxygen species; QS, quinones and semiquinones; IOM, intermediates of melanogenesis; POMC, proopiomelanocortin; CRH, corticotropin-releasing hormone; PCSK1/2, proprotein convertase subtilisin/kexin types 1 and 2. The figure is reprinted from (7) with the permission from the publisher.
Figure 2
Figure 2
Melanin and melanogenesis are a two-edged sword. Melanin acting as a radiation protector and scavenger of cellular toxins will protect normal melanocytes against noxious insults, but will attenuate effectiveness of radiation or chemotherapy (1,6). Furthermore, because of immunosuppressive, genotoxic and mutagenic properties, melanogenesis can enhance tumor growth or induce tumor progression (1,3,6,10).
See this image and copyright information in PMC

Comment on

References

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    1. Plonka PM, Passeron T, Brenner M, et al. Exp Dermatol. 2009;18:799–819. - PMC - PubMed
    1. Slominski A, Tobin DJ, Shibahara S, et al. Physiol Rev. 2004;84:1155–1228. - PubMed
    1. Schallreuter KU, Kothari S, Chavan B, et al. Exp Dermatol. 2008;17:395–404. - PubMed
    1. Slominski A, Kim TK, Brozyna AA, et al. Arch Biochem Biophys. 2014;563:79–93. - PMC - PubMed