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Randomized Controlled Trial
. 2014 Dec 13:13:191.
doi: 10.1186/1476-511X-13-191.

Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naïve patients in Yaounde-Cameroon: a randomized trial study

Marthe-Elise Ngo-Matip  1 , Constant Anatole Pieme, Marcel Azabji-Kenfack, Prosper Cabral Nya Biapa, Nkenfack Germaine, Englert Heike, Bruno Moukette Moukette, Korosky Emmanuel, Stefanini Philippe, Carl Moses Mbofung, Jeanne Yonkeu Ngogang
Affiliations
Randomized Controlled Trial

Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naïve patients in Yaounde-Cameroon: a randomized trial study

Marthe-Elise Ngo-Matip et al. Lipids Health Dis. .

Abstract

Background: Cardiovascular diseases (CVD) and metabolic alterations are among the majors public health concern that have been reported in people living with HIV infections. Factors contributing to cardio metabolic syndrome in HIV include body fat distribution, dyslipidemia, insulin resistance, cardiovascular dysfunction and inflammation. The aim of the study was to determine the effect of Spirulina platensis (Cyanobacteriaceae) supplementation versus local diet on lipid profile in HIV-infected antiretroviral-naive patients.

Methods: A prospective single-blind, randomized, multicentre study was conducted from February 2010 to December 2012. A total of 320 HIV antiretroviral-naïve patients were screened and 169 were recruited in this study. Patients were randomized and received either Spirulina supplementation combined with local diet (n=82) or local diet only (n=87). Age, weight, body mass index (BMI), lipid profile, CD4 count, and local food intake variables were assessed on three separate occasions (three, six and twelve months).

Results: An average age of the patients was 35.6±9 years. The majority of participants were female 67.1%. Regarding the lipid profile, there is a significant increase in HDL-cholesterol and a significant decrease in total cholesterol, LDL-cholesterol and triglycerides in the group of patients who consumed Spirulina platensis. A change in the atherogenic index defined by the ratio CT/HDL-C substitutable by LDL-C/HDL-C and the TC/HDL decreased significantly from 10.83 at baseline to 2.22 after 12 months (p=0.21 and p<0.0001) in the patients taking Spirulina.

Conclusions: Nutritional supplementation with Spirulina combined with a quantitative and qualitative balanced diet for at least six months can retard an exposition to lipid abnormalities in HIV-infected antiretroviral-naive patients. Further studies are recommended on a large group of people not infected with HIV and exposed to cardiovascular risk factors.

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Figures

Figure 1
Figure 1
Flow chart describing progress of participants through the Spirulina platensis supplementation trial.
Figure 2
Figure 2
Concentration of triglycerides levels of the two groups of patients during the trial.
Figure 3
Figure 3
Concentration of total cholesterol levels of the two groups during the trial.
Figure 4
Figure 4
Concentration of HDL-Cholesterol levels of the two groups during the trial.
Figure 5
Figure 5
Concentration of LDL cholesterol of the two groups during the trial.
Figure 6
Figure 6
Concentration of artherogenic index of the patients in the two groups during the trial.
See this image and copyright information in PMC

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