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. 2015 Jan 27:90:577-82.
doi: 10.1016/j.ejmech.2014.12.007. Epub 2014 Dec 5.

Synthesis, anticandidal activity of N(3)-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives--novel inhibitors of glucosamine-6-phosphate synthase

Dorota Pawlak  1 , Magdalena Stolarska  1 , Marek Wojciechowski  1 , Ryszard Andruszkiewicz  2
Affiliations

Synthesis, anticandidal activity of N(3)-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives--novel inhibitors of glucosamine-6-phosphate synthase

Dorota Pawlak et al. Eur J Med Chem. .

Abstract

Novel FMDP amides 4-6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from C. albicans.

Keywords: Antifungal activity; FMDP analogs; Glucosamine-6-phosphate synthase inhibitors; Molecular modeling.

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