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. 2014 Dec 10:349:g7518.
doi: 10.1136/bmj.g7518.

Ebola virus vaccine trials: the ethical mandate for a therapeutic safety net

Steve E Bellan  1 , Juliet R C Pulliam  2 , Jonathan Dushoff  3 , Lauren Ancel Meyers  4
Affiliations

Ebola virus vaccine trials: the ethical mandate for a therapeutic safety net

Steve E Bellan et al. BMJ. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

None
Anticipated number of deaths among participants by trial arm in a hypothetical vaccine trial, with and without a treatment that reduces the case fatality rate by 70%. The therapeutic safety net reduces overall mortality and, crucially, also substantially bridges the gap between the two arms, thereby facilitating clinical equipoise. Following vaccine trial proposals, we assume that 30 participants will become infected before the trial reaches its stopping criteria. All assumptions are explained in the supplementary code (http://ebola.ici3d.org/BMJ/equipoise.R)
See this image and copyright information in PMC

References

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