Pathogens' exploitation of the intestinal food web
- PMID: 25498340
- DOI: 10.1016/j.chom.2014.11.012
Pathogens' exploitation of the intestinal food web
Abstract
Competition for nutrients is a key factor controlling pathogen colonization within the gastrointestinal tract. In this issue, Ferreyra et al. (2014) and Curtis et al. (2014) show that diverse enteric pathogens can exploit a metabolic byproduct from the commensal microbiota, succinate, to enhance their own virulence expression and proliferation.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.Cell Host Microbe. 2014 Dec 10;16(6):759-69. doi: 10.1016/j.chom.2014.11.005. Cell Host Microbe. 2014. PMID: 25498343 Free PMC article.
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Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance.Cell Host Microbe. 2014 Dec 10;16(6):770-7. doi: 10.1016/j.chom.2014.11.003. Cell Host Microbe. 2014. PMID: 25498344 Free PMC article.
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