Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jul 1;261(1):293-6.
doi: 10.1042/bj2610293.

Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion

T B McCall  1 , N K Boughton-Smith, R M Palmer, B J Whittle, S Moncada
Affiliations

Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion

T B McCall et al. Biochem J. .

Abstract

Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.

PubMed Disclaimer

References

    1. Acta Biochim Biophys Acad Sci Hung. 1977;12(3):191-6 - PubMed
    1. Biochem Pharmacol. 1989 Jun 1;38(11):1709-15 - PubMed
    1. Science. 1981 Apr 3;212(4490):56-8 - PubMed
    1. Thromb Res. 1983 May 15;30(4):383-9 - PubMed
    1. J Immunol Methods. 1985 Apr 8;78(1):35-47 - PubMed