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. 2015 Apr;36(4):2869-73.
doi: 10.1007/s13277-014-2915-8. Epub 2014 Dec 14.

Cyr61 promotes growth of glioblastoma in vitro and in vivo

Gang Cheng  1 , Hangyu Zhang, Leiming Zhang, Jianning Zhang
Affiliations
Free article

Cyr61 promotes growth of glioblastoma in vitro and in vivo

Gang Cheng et al. Tumour Biol. 2015 Apr.
Free article

Abstract

The molecular regulation of the growth of glioblastoma (GBM) is not completely understood. Here, we show that the Cyr61 levels were significantly higher in GBM than in the adjacent non-tumor tissues. Overexpression of Cyr61 enhanced the viability of GBM cells, while inhibition of Cyr61 decreased the viability of GBM cells, in vitro and in vivo. Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling pathway to increase cell growth in GBM cells. Taken together, our findings suggest a potential role of Cyr61 in GBM growth and highlight Cyr61 as a novel target for GBM therapy.

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