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. 1989;50(2-3):161-4.
doi: 10.1159/000132750.

Analysis of complex Y chromosome aberrations using a single DNA probe (Y-367)

U Müller  1 , D Fontaine, M Adinolfi, M Fraccaro, M Lalande
Affiliations

Analysis of complex Y chromosome aberrations using a single DNA probe (Y-367)

U Müller et al. Cytogenet Cell Genet. 1989.

Abstract

A specific cloned DNA sequence (Y-367) detects at least four loci in the euchromatic long arm and in the short arm of the human Y chromosome. Deletion mapping assigns one locus to the distal euchromatic long arm, another to a region close to the centromere on either Yq or Yp, and two additional loci to the Y short arm. Y-367 may thus be used for the rapid screening of even complex Y chromosome aberrations. This is exemplified in a 45,X male with Y chromosome material on the long arm of chromosome 10 by the detection of an inversion of a portion of Yp and by the confirmation of duplications and deletions in two individuals with duplications of part of the Y chromosome.

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