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Meta-Analysis
. 2014 Dec 11:20:2617-23.
doi: 10.12659/MSM.891017.

A meta-analysis of IL-13 polymorphisms and pediatric asthma risk

Zhigang Liu  1 , Peijie Li  1 , Jinrong Wang  2 , Qing Fan  1 , Ping Yan  1 , Xiaojing Zhang  1 , Bo Han  2
Affiliations
Meta-Analysis

A meta-analysis of IL-13 polymorphisms and pediatric asthma risk

Zhigang Liu et al. Med Sci Monit. .

Abstract

Background: IL13-1112C/T and +2044A/G polymorphisms have been reported to be correlated with pediatric asthma susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted.

Material/methods: PubMed and EMBASE databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model.

Results: Fourteen case-control studies with 4710 asthma cases and 6086 controls were included in this meta-analysis. IL13-1112C/T and +2044A/G polymorphisms were significantly associated with an increased risk of pediatric asthma (OR=1.14, 95% CI 1.01-1.28, P=0.04, I2=0%; OR=1.20, 95% CI 1.09-1.32, P<0.01, I2=0%), respectively. In the subgroup analysis by ethnicity, IL13-1112C/T polymorphism was significantly associated with pediatric asthma risk in whites (OR=1.29, 95% CI 1.02-1.63, P=0.03, I2=16%). IL13 +2044A/G polymorphism was significantly associated with pediatric asthma risk in Asians (OR=1.21, 95% CI 1.10-1.34, P<0.01, I2=24%).

Conclusions: The results of this meta-analysis suggest that IL13-1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma.

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Figures

Figure 1
Figure 1
Meta-analysis of the association between the IL13–1112C/T polymorphism and pediatric asthma risk.
Figure 2
Figure 2
Funnel plot for the IL13–1112C/T polymorphism and pediatric asthma risk.
Figure 3
Figure 3
Meta-analysis of the association between the IL13 +2044A/G polymorphism and pediatric asthma risk.
Figure 4
Figure 4
Funnel plot for the IL13 +2044A/G polymorphism and pediatric asthma risk.
Figure 5
Figure 5
The process of study selection.
See this image and copyright information in PMC

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