Hepatitis B virus infection in liver cirrhosis and hepatocellular carcinoma in Jakarta Indonesia

Abstract

The relationship between hepatitis B virus (HBV) infection and 144 cases with liver cirrhosis (LC) and 82 cases with hepatocellular carcinoma (HCC), admitted to the Department of Internal Medicine, Dr. Cipto Mangunkusmo Hospital in Jakarta, was investigated within the period from January 1 until December 31, 1984. The prevalence of HBsAg in 144 cases with LC was 41.1%, anti-HBs 33.3% and anti-HBc alone 16.0%. In only 9.0% no markers were found. The prevalence of HBeAg in 60 cases HBsAg positive LC was 35.0%, anti-HBe was 41.7% and in 23.3% both markers were negative. Among 82 cases with HCC, the prevalence of HBsAg was 47.6%, anti-HBs was 25.6% and anti-HBc alone was 15.9%. The prevalence of HBeAg in 39 cases with HCC was 25.6%, anti-HBe was 51.3% and in 23.1% both markers were negative. Age distribution between HBsAg positive and negative in LC was observed significant difference (P less than 0.05). Mean age of HBsAg positive group in LC was 5 years younger than that of the HBsAg negative group.