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. 2014 Dec;34(12):7167-75.

PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected]

Juozas Kupcinskas  1 , Thomas Wex  2 , Alexander Link  3 , Ruta Bartuseviciute  4 , Milda Dedelaite  4 , Gintare Kevalaite  4 , Marcis Leja  5 , Jurgita Skieceviciene  6 , Gediminas Kiudelis  1 , Laimas Jonaitis  1 , Limas Kupcinskas  7 , Peter Malfertheiner  3
Affiliations
  • PMID: 25503145

PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected]

Juozas Kupcinskas et al. Anticancer Res. 2014 Dec.

Erratum in

  • Errata.
    [No authors listed] [No authors listed] Anticancer Res. 2015 May;35(5):3109. Anticancer Res. 2015. PMID: 25964603 No abstract available.

Abstract

Background/aim: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG).

Materials and methods: Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls.

Results: PSCA rs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCA rs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223.

Conclusion: Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.

Keywords: MUC1; PLCE1; PSCA; SNP; gastric cancer; gastritis; gene polymorphism.

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