Transcription factors and epigenetic modulation: its therapeutic implication in chronic kidney disease
- PMID: 25503375
- DOI: 10.1007/s00005-014-0326-6
Transcription factors and epigenetic modulation: its therapeutic implication in chronic kidney disease
Abstract
Recently emerging evidence has shown that epigenetic mechanisms are involved in initiation and progression of various diseases, including kidney diseases. In the present article, we review the current data regarding the role of epigenetic modulation in chronic kidney disease (CKD) and kidney fibrosis, including DNA methylation and histone modification. Especially we focused on the role of transcription factors in epigenetic modulation and the possibility of therapeutic target of CKD. We have recently reported that transcription factor Kruppel-like factor 4 (also known as gut-enriched Kruppel-like factor) is expressed in kidney podocytes (visceral epithelial cells) and modulates podocyte phenotype by gene-selective epigenetic control. Targeting transcription factors for epigenetic modification may be a good candidate for remission and regression of CKD. It is necessary for the therapy of CKD with an epigenetic-based approach to investigate organ-, tissue-, or gene-specific treatment methods for reduction of side effects.
Similar articles
-
[Therapeutic effect of RAS inhibitors on epigenetic changes in life-style related diseases].Nihon Rinsho. 2015 Nov;73(11):1933-8. Nihon Rinsho. 2015. PMID: 26619671 Japanese.
-
DNA Damage and Epigenetic Changes in Kidney Diseases - Focused on Transcription Factors in Podocytes.Curr Hypertens Rev. 2016;12(2):105-11. doi: 10.2174/1573402112666160302102408. Curr Hypertens Rev. 2016. PMID: 26931473 Review.
-
Transcription Factors as Therapeutic Targets in Chronic Kidney Disease.Molecules. 2018 May 9;23(5):1123. doi: 10.3390/molecules23051123. Molecules. 2018. PMID: 29747407 Free PMC article. Review.
-
Current epigenetic aspects the clinical kidney researcher should embrace.Clin Sci (Lond). 2017 Jun 30;131(14):1649-1667. doi: 10.1042/CS20160596. Print 2017 Jul 15. Clin Sci (Lond). 2017. PMID: 28667065 Review.
-
Epigenetic control of podocyte differentiation: a new target of the renin-angiotensin system in kidney disease.Kidney Int. 2015 Oct;88(4):668-70. doi: 10.1038/ki.2015.224. Kidney Int. 2015. PMID: 26422623
Cited by
-
Transcriptional Signatures and Network-Based Approaches Identified Master Regulators Transcription Factors Involved in Experimental Periodontitis Pathogenesis.Int J Mol Sci. 2023 Oct 2;24(19):14835. doi: 10.3390/ijms241914835. Int J Mol Sci. 2023. PMID: 37834287 Free PMC article.
-
Krϋppel-like factors (KLFs) in renal physiology and disease.EBioMedicine. 2019 Feb;40:743-750. doi: 10.1016/j.ebiom.2019.01.021. Epub 2019 Jan 17. EBioMedicine. 2019. PMID: 30662001 Free PMC article. Review.
-
Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.PLoS One. 2021 Mar 18;16(3):e0248854. doi: 10.1371/journal.pone.0248854. eCollection 2021. PLoS One. 2021. PMID: 33735324 Free PMC article.
-
The Role of Krüppel-like Factor 4 in Renal Fibrosis.Front Physiol. 2015 Nov 12;6:327. doi: 10.3389/fphys.2015.00327. eCollection 2015. Front Physiol. 2015. PMID: 26617530 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical