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. 2015 Feb 2;54(6):1914-8.
doi: 10.1002/anie.201410717. Epub 2014 Dec 12.

Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry

Aiichiro Nagaki  1 , Keita Imai, Satoshi Ishiuchi, Jun-ichi Yoshida
Affiliations
Free article

Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry

Aiichiro Nagaki et al. Angew Chem Int Ed Engl. .
Free article

Abstract

Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting-group-free synthesis using organolithium compounds and opens a new possibility in the synthesis of polyfunctional organic molecules.

Keywords: chemoselectivity; flash chemistry; flow chemistry; microreactors; organolithium compounds.

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