The Virtual Patient Simulator of Deep Brain Stimulation in the Obsessive Compulsive Disorder Based on Connectome and 7 Tesla MRI Data

Abstract

We present work in progress on the virtual patient model for patients with Deep Brain Stimulation (DBS) implants based on Connectome and 7 Tesla Magnetic Resonance Imaging (MRI) data. Virtual patients are realistic computerized models of patients that allow medical-device companies to test new products earlier, helping the devices get to market more quickly and cheaply according to the Food and Drug Administration. We envision that the proposed new virtual patient simulator will enable radio frequency power dosimetry on patients with the DBS implant undergoing MRI. Future patients with DBS implants may profit from the proposed virtual patient by allowing for a MRI investigation instead of more invasive Computed Tomography (CT) scans. The virtual patient will be flexible and morphable to relate to neurological and psychiatric conditions such as Obsessive Compulsive Disorder (OCD), which benefit from DBS.

Keywords: 7 Tesla MRI; CT; DBS; MRI; MRI safety; OCD; SAR; VPS; connectome; deep brain brain stimulation; obsessive compulsive disorder; specific absorption rate; virtual patient simulator.

Fig. 1

(A) Coronal section at the C.A.P. (Caudate-Accumbens-Putamen) level of a 7T high-resolution (100 µm3 isotropic) ex-vivo human dataset showing detailed anatomy of the VC/VS target area (cross-hair in red) within the anterior limb of the internal capsule. (B) : (left) DSI connectome data set, (middle) electrode placement in the VC/VS target area traversed by fibers (yellow fibers) of the ventromedial prefrontal-basal ganglia tract at the C.A.P. coronal slice. The latter fibers stem from the ventromedial prefrontal area (yellow block). (A=nucleus accumbens, C=caudate nucleus, P=putamen), and (right) electrode geometry with the proposed embedded thin solid state temperature sensor film (red).

Fig. 2

(Left) Geometrical model of the coil array and our model [13] with examples of null (A) and uniform (B) φ⃗ vectors [17]. (Right) 8-channel transmit phase array FDTD B₁ maps (nT/ampere) of the center transverse slice of our model when each channel is driven with a 1-ampere peak-to-peak 300-MHz sinusoid [18].