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Review
. 2014:2014:138016.
doi: 10.1155/2014/138016. Epub 2014 Nov 24.

Relevance of chronic lyme disease to family medicine as a complex multidimensional chronic disease construct: a systematic review

Liesbeth Borgermans  1 , Geert Goderis  2 , Jan Vandevoorde  1 , Dirk Devroey  1
Affiliations
Review

Relevance of chronic lyme disease to family medicine as a complex multidimensional chronic disease construct: a systematic review

Liesbeth Borgermans et al. Int J Family Med. 2014.

Abstract

Lyme disease has become a global public health problem and a prototype of an emerging infection. Both treatment-refractory infection and symptoms that are related to Borrelia burgdorferi infection remain subject to controversy. Because of the absence of solid evidence on prevalence, causes, diagnostic criteria, tools and treatment options, the role of autoimmunity to residual or persisting antigens, and the role of a toxin or other bacterial-associated products that are responsible for the symptoms and signs, chronic Lyme disease (CLD) remains a relatively poorly understood chronic disease construct. The role and performance of family medicine in the detection, integrative treatment, and follow-up of CLD are not well studied either. The purpose of this paper is to describe insights into the complexity of CLD as a multidimensional chronic disease construct and its relevance to family medicine by means of a systematic literature review.

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References

    1. Krupka M., Zachova K., Weigl E., Raska M. Prevention of lyme disease: promising research or sisyphean task? Archivum Immunologiae et Therapiae Experimentalis. 2011;59(4):261–275. doi: 10.1007/s00005-011-0128-z. - DOI - PubMed
    1. Clark K. L., Leydet B. F., Threlkeld C. Geographical and genospecies distribution of borrelia burgdorferi sensu lato DNA detected in humans in the USA. Journal of Medical Microbiology. 2014;63(5):674–684. doi: 10.1099/jmm.0.073122-0. - DOI - PubMed
    1. Lewandowska A., Kruba Z., Filip R. Epidemiology of Lyme disease among workers of forest inspectorates in Poland. Annals of Agricultural and Environmental Medicine. 2013;20(2):329–331. - PubMed
    1. Biesiada G., Czepiel J., Leśniak M. R., Garlicki A., Mach T. Lyme disease: review. Archives of Medical Science. 2012;8(6):978–982. doi: 10.5114/aoms.2012.30948. - DOI - PMC - PubMed
    1. Coburn J., Leong J., Chaconas G. Illuminating the roles of the Borrelia burgdorferi adhesins. Trends in Microbiology. 2013;21(8):372–379. doi: 10.1016/j.tim.2013.06.005. - DOI - PMC - PubMed